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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RET All Species: 10
Human Site: S1034 Identified Species: 20
UniProt: P07949 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P07949 NP_065681.1 1114 124319 S1034 L I Y D D G L S E E E T P L V
Chimpanzee Pan troglodytes XP_001171246 813 90715 R735 W H A V P S Q R P T F K Q L V
Rhesus Macaque Macaca mulatta XP_001090823 731 81824 R653 W H A V P S Q R P T F K Q L V
Dog Lupus familis XP_543915 1108 124018 S1028 L L Y D D G L S E E E T P L V
Cat Felis silvestris
Mouse Mus musculus P35546 1115 123855 S1035 L L Y D D G L S E E E T P L V
Rat Rattus norvegicus Q04589 822 91806 R744 W N A V P S Q R P T F K Q L V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507715 665 75620 E587 Y D D G L S E E E T P L V D C
Chicken Gallus gallus P18461 823 92281 V745 M R D C W Q A V P S Q R P T F
Frog Xenopus laevis Q03364 813 91322 S735 D C W H A I P S H R P T F K Q
Zebra Danio Brachydanio rerio Q8JG38 817 91370 I739 M K D C W H A I S S H R P T F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q09147 1052 117795 V974 C S L N I Y V V M R Q C W H F
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus Q26614 972 110463 C894 I Y H I L C E C W R T S P G Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 28.4 27.9 86.4 N.A. 83.4 28.9 N.A. 43 27.5 28.1 27.7 N.A. 23.6 N.A. N.A. 24
Protein Similarity: 100 42.2 41.5 92 N.A. 90.2 43 N.A. 50.5 43.5 42.3 42 N.A. 37.7 N.A. N.A. 41.2
P-Site Identity: 100 13.3 13.3 93.3 N.A. 93.3 13.3 N.A. 6.6 6.6 13.3 6.6 N.A. 0 N.A. N.A. 6.6
P-Site Similarity: 100 13.3 13.3 100 N.A. 100 13.3 N.A. 6.6 20 20 13.3 N.A. 20 N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 25 0 9 0 17 0 0 0 0 0 0 0 0 % A
% Cys: 9 9 0 17 0 9 0 9 0 0 0 9 0 0 9 % C
% Asp: 9 9 25 25 25 0 0 0 0 0 0 0 0 9 0 % D
% Glu: 0 0 0 0 0 0 17 9 34 25 25 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 25 0 9 0 25 % F
% Gly: 0 0 0 9 0 25 0 0 0 0 0 0 0 9 0 % G
% His: 0 17 9 9 0 9 0 0 9 0 9 0 0 9 0 % H
% Ile: 9 9 0 9 9 9 0 9 0 0 0 0 0 0 0 % I
% Lys: 0 9 0 0 0 0 0 0 0 0 0 25 0 9 0 % K
% Leu: 25 17 9 0 17 0 25 0 0 0 0 9 0 50 0 % L
% Met: 17 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % M
% Asn: 0 9 0 9 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 25 0 9 0 34 0 17 0 50 0 0 % P
% Gln: 0 0 0 0 0 9 25 0 0 0 17 0 25 0 17 % Q
% Arg: 0 9 0 0 0 0 0 25 0 25 0 17 0 0 0 % R
% Ser: 0 9 0 0 0 34 0 34 9 17 0 9 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 34 9 34 0 17 0 % T
% Val: 0 0 0 25 0 0 9 17 0 0 0 0 9 0 50 % V
% Trp: 25 0 9 0 17 0 0 0 9 0 0 0 9 0 0 % W
% Tyr: 9 9 25 0 0 9 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _